Centers

Characterization

Characterization

Awardee Institution Title Award Number Jay Shendure, Nadav Ahituv, Martin Kircher University of Washington, UC San Francisco, Charite Universitatsmedizin Berlin Massively parallel characterization of variants and elements impacting transcriptional regulation in dynamic cellular systems HG011966 Lea Starita, Douglas Fowler University of Washington The Center for Actionable Variant Analysis; measuring variant function at scale HG011969 Jesse Engreitz, Thomas Quertermous Stanford University Stanford Center for Connecting DNA Variants to Function and Phenotype HG011972 Marc Vidal Dana-Farber Cancer Institute Molecular phenotyping of ~100,000 coding variants across Mendelian disease genes HG011989 Gary Hon, William Kraus, Nikhil Munshi University of Texas Southwestern Medical Center Multiscale functional characterization of genomic variation in human developmental disorders HG011996 Hyejung Won, Michael Love, Karen Mohlke University of North Carolina at Chapel Hill Systematic in vivo characterization of disease-associated regulatory variants HG012003 Luca Pinello, Daniel Bauer, Guillaume Lettre, Richard Sherwood Massachusetts General Hospital, Children’s Hospital Boston, Montreal Heart Institute, Brigham and Women’s Hospital Comprehensive characterization of variants underlying heart and blood diseases with CRISPR base editing HG012010 Charles Gersbach, Gregory Crawford, Tim Reddy Duke University High-throughput functional annotation of gene regulatory elements and variants critical to complex cellular phenotypes HG012053

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Data and Administrative Coordinating Center

Data and Administrative Coordinating Center

Awardee Institution Title Award Number J. Michael Cherry, Mark Gerstein Stanford University, Yale University A Data and Administrative Coordinating Center for the Impact of Genomic Variation on Function Consortium HG012012 Ting Wang, Feng Yue Washington University Saint Louis, Northwestern University WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating Center HG012070

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Mapping

Mapping

Awardee Institution Title Award Number Jason Buenrostro, Bradley Bernstein Broad Institute, Harvard University, Broad Institute, Massachusetts General Hospital A foundational resource of functional elements, TF footprints and gene regulatory interactions HG011986 Ansuman Satpathy Stanford University Single-cell Mapping Center for Human Regulatory Elements and Gene Activity HG012076 Seyed Mortazavi, Barbara Wold UC Irvine, California Institute of Technology Center for Mouse Genomic Variation at Single Cell Resolution HG012077

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