The IGVF (Impact of Genomic Variation on Function) Consortium aims to understand how genomic variation affects genome function, which in turn impacts phenotype. IGVF advances functional genomics by generating and sharing large-scale data and resources that enable researchers to understand how genetic variation influences genome function, phenotype, and human disease. The NHGRI, an institute within the NIH, funds this collaborative program and brings together teams of investigators who use state-of-the-art experimental and computational approaches to model, predict, characterize, and map genome function to study: how genome function shapes phenotype, and how these processes are affected by genomic variation. Through these joint efforts, IGVF is cataloging the impact of genomic variants on genome function and phenotypes.